Cingulate gyral reductions are related to low executive functioning and psychotic symptoms in 22q11.2 deletion syndrome

NEUROPSYCHOLOGIA

卷:46

Article

Dufour, Federico¹  Schaer, Marie^1,4  Debbane, Martin^1,2  Farhoumand, Riaz¹  Glaser, Bronwyn^1,2  Eliez, Stephan^1,3 

[1] Univ Geneva, Sch Med, Dept Psychiat, Med Serv,Pedag Res Unit, CH-1211 Geneva 8, Switzerland

[2] Univ Geneva, Fac Psychol, CH-1211 Geneva 4, Switzerland

[3] Univ Geneva, Sch Med, Dept Genet Med & Dev, CH-1211 Geneva 4, Switzerland

[4] Swiss Fed Inst Technol, Signal Proc Inst, CH-1015 Lausanne, Switzerland

关键词: cingulate gyrus;    neuroimaging;    psychosis;    velo-cardio-facial;    executive function;    schizophrenia;   

DOI  :  10.1016/j.neuropsychologia.2008.06.012

来源: Elsevier

【 摘 要 】

A similar pattern of deficits in executive function and neuroanatomical abnormalities is shared between 22q11.2 deletion syndrome (22q11DS) and schizophrenia, suggesting that common cerebral alterations may lead to cognitive dysfunction and promote the appearance of psychotic symptoms in 22q11DS individuals. Specifically, there is increasing evidence for involvement of the cingulate gyros (CG) in executive dysfunction and the expression of positive symptoms in schizophrenia. The aim of our study is to examine CC morphology in a 22q11DS population and its potential role as a cerebral marker of executive dysfunction and the manifestation of psychotic symptoms. Using region of interest (ROI)-based analysis, we compared CC volumes from 58 children and adults affected by 22q11DS with 64 healthy age- and gender-matched controls. After covarying for total cranium grey matter and age, a bilateral reduced CC grey matter volume, driven by a decrease in anterior CC cortex, was observed among 22q11DS patients. Further post hoc analyses Suggest correlations between right CC cortical reductions, low-executive functioning and the Occurrence of psychotic symptoms. The CC structural abnormalities observed in 22q11DS are consistent with previous reports in schizophrenic patients and are associated with pre-morbid cognitive impairments. The mechanisms by which these changes may modulate executive functioning and the expression of psychosis are discussed. (C) 2008 Elsevier Ltd. All rights reserved.

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