Prefrontal gray matter increases in healthy individuals after lithium treatment: A voxel-based morphometry study

NEUROSCIENCE LETTERS

卷:429

Article

Monkul, E. Serap^2,3  Matsuo, Koji²  Nicoletti, Mark A.^1,2  Dierschke, Nicole²  Hatch, John P.^2,4  Dalwani, Manish²  Brambilla, Paolo^5,6  Caetano, Sheila^2,7  Sassi, Roberto B.⁸  Mallinger, Allan G.⁸  Soares, Jair C.^1,2 

[1] Univ N Carolina, Sch Med, Dept Psychiat, CERT BD, Chapel Hill, NC 27599 USA

[2] Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, San Antonio, TX 78229 USA

[3] Dokuz Eylul Univ, Sch Med, Dept Psychiat, Izmir, Turkey

[4] Univ Texas Hlth Sci Ctr San Antonio, Dept Orthodont, San Antonio, TX 78229 USA

[5] Univ Udine, Dept Pathol & Expt & Clin Med, Sect Psychiat, I-33100 Udine, Italy

[6] IRCCS E Medea, Inst Sci, Rome, Italy

[7] Univ Sao Paulo, Sch Med, Dept Psychiat, Sao Paulo, Brazil

[8] Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, Dept Psychiat, Pittsburgh, PA USA

关键词: lithium;    neuroprotection;    neuroimaging;    cingulate gyrus;    white matter;   

DOI  :  10.1016/j.neulet.2007.09.074

来源: Elsevier

【 摘 要 】

The objective of this study was to test the hypothesis that 4 weeks of lithium administration would be associated with changes in brain gray and white matter volumes in healthy individuals. Thirteen right-handed healthy volunteers (6 females, mean age = 25.9 +/- 10.0 years) were studied. 3D SPGR MRIs (TR=25 ms, TE=5 ms, slice-thickness= 1.5 mm) were acquired using a 1.5 T GE Signa Imaging System, at baseline and after 4 weeks of lithium administration at therapeutically relevant doses. Optimized voxel-based morphometry (VBM) analyses were conducted. Left and right dorsolateral prefrontal cortex and left anterior cingulate gray matter volumes increased significantly following lithium administration. Total white matter volume was increased, whereas total brain volume and total gray matter volume were not significantly changed following 4 weeks of lithium. Lithium treatment resulted in prefrontal regional gray matter volume increases in healthy volunteers, as well as increases in total white matter volume. Whether these changes are mediated by neurotrophic/neuroprotective or osmotic effects remains unknown. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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