Feasibility and outcome of a web-based self-help intervention for depressive symptoms in patients with multiple sclerosis: A pilot study

JOURNAL OF THE NEUROLOGICAL SCIENCES

卷:315

Article

Boeschoten, Rosa E.^1,2,3  Nieuwenhuis, Magdalena M.^2,3  van Oppen, Patricia^2,3  Uitdehaag, Bernard M. J.^3,5  Polman, Chris H.^3,5  Collette, Emma H.⁶  Cuijpers, Pim^3,4  Beekman, Aartjan T. F.^2,3  Dekker, Joost^2,3 

[1] GGZinGeest, Acad Anxiety Outpatient Clin, VU Med Ctr, NL-1081 HL Amsterdam, Netherlands

[2] Vrije Univ Amsterdam Med Ctr, Dept Psychiat, Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, EMGO Inst Mental Hlth & Care Res, Amsterdam, Netherlands

[4] Vrije Univ Amsterdam, Dept Clin Psychol, Amsterdam, Netherlands

[5] Vrije Univ Amsterdam Med Ctr, Dept Neurol, Amsterdam, Netherlands

[6] Vrije Univ Amsterdam Med Ctr, Dept Med Psychol, Amsterdam, Netherlands

关键词: Depression;    Multiple sclerosis;    Internet;    Treatment;    Anxiety;    Pilot study;   

DOI  :  10.1016/j.jns.2011.11.016

来源: Elsevier

【 摘 要 】

Background: Depressive symptoms are highly prevalent among patients with multiple sclerosis (MS). Web-based problem solving therapy (PST) is easily accessible and showed to be effective in depressed patients. Objectives: The aims of this pilot study were to examine feasibility and outcome (reduction of depressive symptoms) of an applied web-based PST intervention in MS patients. Methods: Forty-four MS patients with mild to severe depressive symptoms followed a web-based PST intervention. Feasibility was measured by compliance rate and satisfaction scales. The Beck Depression Inventory (BDI-II) was used to measure depressive symptoms before and after the intervention. Results: The compliance rate was 52%, and 85% of the patients rated the quality of the intervention as good or excellent. After the intervention, depressive symptoms had significantly decreased (BDI-II change: mean = -3.9, p = 0.01, d = 0.51 in intention-to-treat analysis; BDI-II change: mean = -9.0, p < 0.001. d = 1.50 in completers analysis). Conclusions: This study suggests that applied web-based PST is feasible and reduces depressive symptoms in MS patients. Especially MS patients who experience disease-related or other barriers to participate in face-to-face counselling could benefit. However, ways to increase compliance should be considered. A randomized controlled trial is recommended to more extensively investigate effectiveness of this intervention in treating depressive symptoms in MS patients. (C) 2011 Elsevier B.V. All rights reserved.

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