Histopathologic evaluation of basilar artery atherosclerosis

JOURNAL OF THE NEUROLOGICAL SCIENCES

卷:307

Article

Labadzhyan, Artak⁵  Csiba, Laszlo²  Narula, Navneet³  Zhou, Jun⁵  Narula, Jagat⁵  Fisher, Mark^1,3,4 

[1] UC Irvine, Dept Neurol, UC Irvine Med Ctr, Orange, CA 92868 USA

[2] Univ Debrecen, Dept Neurol, Debrecen, Hungary

[3] UC Irvine, Dept Pathol & Lab Med, Orange, CA 92868 USA

[4] UC Irvine, Dept Anat & Neurobiol, Orange, CA 92868 USA

[5] UC Irvine, Dept Med, Orange, CA 92868 USA

关键词: Intracranial;    Atherosclerosis;    Stroke;    Basilar;    Plaque;    Artery;   

DOI  :  10.1016/j.jns.2011.05.004

来源: Elsevier

【 摘 要 】

Introduction: There has been limited attention to pathological features of basilar artery atherosclerosis. It has been assumed that pathology of basilar artery atherosclerosis mimics that of other vascular beds. Methods: To define the nature of the basilar artery atherosclerotic lesions, we analyzed postmortem intracranial artery samples from eight subjects with history of stroke. Results: Atherosclerotic lesions were present in 7/8 arteries examined, with a mean estimated stenosis of 34%. Lumen thrombus with a disrupted fibrous cap was seen in 1 lesion: the remaining 6 lesions revealed a thick fibrous cap. Neovascularity and calcification were seen in 1 lesion and mild to moderate inflammation was seen in 3 lesions. Necrotic core was present in 4/7 lesions, and was associated with plague rupture in the only disrupted lesion. Conclusions: Basilar artery atherosclerotic lesions were relatively benign in this series of patients presenting with stroke. While confirmation is needed with larger sample size, the relative paucity of neovascularity suggests a possibly distinctive histopathological profile. (C) 2011 Elsevier B.V. All rights reserved.

【 授权许可】

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