Auditory evoked potentials and vestibular evoked myogenic potentials in evaluation of brainstem lesions in multiple sclerosis

JOURNAL OF THE NEUROLOGICAL SCIENCES

卷:328

Article

Ivankovic, Anita^1,2  Madaric, Vesna Nesek¹  Starcevic, Katarina¹  Skoric, Magdalena Krbot¹  Gabelic, Tereza¹  Adamec, Ivan¹  Habek, Mario^1,3 

[1] Univ Hosp Ctr Zagreb, Referral Ctr Demyelinating Dis Cent Nervous Syst, Dept Neurol, Zagreb, Croatia

[2] Univ Hosp Mostar, Dept Neurol, Mostar, Bosnia & Herceg

[3] Univ Zagreb, Sch Med, Zagreb 41001, Croatia

关键词: Auditory evoked potentials;    Vestibular evoked myogenic potentials;    Brainstem;    Multiple sclerosis;   

DOI  :  10.1016/j.jns.2013.02.005

来源: Elsevier

【 摘 要 】

Objective: The aim of this study was to determine the roles of magnetic resonance imaging (MRI), auditory evoked potentials (AEP) and vestibular evoked myogenic potentials (VEMP) in the evaluation of brainstem involvement in multiple sclerosis (MS). Patients and methods: Altogether 32 patients with the diagnosis of MS participated in the study. The following data was collected from all patients: age, gender, Expanded Disability Status Scale (EDSS) score, brainstem functional system score (BSFS) (part of the EDSS evaluating brainstem symptomatology), and involvement of the brainstem on the brain MRI. AEP and ocular VEMP (oVEMP) and cervical VEMP (cVEMP) were studied in all patients. Results: BSFS, MRI,AEP, oVEMP and cVEMP involvement of the brainstem was evident in 9 (28.1%), 14 (43.8%), 7 (21.9%), 12 (37.5%) and 10 (31.0%) patients, respectively. None of the tests used showed statistically significant advantage in the detection of brainstem lesions. When combining oVEMP and cVEMP 18 (56.3%) patients showed brainstem involvement. This combination showed brainstem involvement in greater percentage than BSFS or AEP, with statistical significance (p = 0.035 and p = 0.007, respectively). Conclusion: VEMP is a reliable method in detection of brainstem involvement in MS. It is comparable with MRI, but superior to clinical examination or AEP. (c) 2013 Elsevier B.V. All rights reserved.

【 授权许可】

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