Biopsy-negative, varicella zoster virus (VZV)-positive giant cell arteritis, zoster, VZV encephalitis and ischemic optic neuropathy, all in one

JOURNAL OF THE NEUROLOGICAL SCIENCES

卷:343

Article

Teodoro, Tiago¹  Nagel, Maria A.²  Geraldes, Ruth¹  White, Teresa³  Mahalingam, Ravi³  Batista, Paulo¹  Wellish, Mary³  Pimentel, Jose²  Khmeleva, Nelly³  Heintzman, Anna³  Albuquerque, Luisa¹  Boyer, Philip J.⁵  Choe, Alexander³  Peralta, Rita¹  Gilden, Don^3,4 

[1] Hosp Santa Maria, Dept Neurol, Lisbon, Portugal

[2] Hosp Santa Maria, Dept Neuropathol, Lisbon, Portugal

[3] Univ Colorado, Sch Med, Dept Neurol, Aurora, CO 80045 USA

[4] Univ Colorado, Sch Med, Dept Microbiol, Aurora, CO 80045 USA

[5] Univ Colorado, Sch Med, Dept Pathol, Aurora, CO 80045 USA

关键词: Varicella zoster virus;    Giant cell arteritis;    Ischemic optic neuropathy;    Zoster;    Encephalitis;   

DOI  :  10.1016/j.jns.2014.05.035

来源: Elsevier

【 摘 要 】

A 72-year-old man developed clinical features of giant cell arteritis (GCA) and ipsilateral ophthalmic-distribution zoster, followed within 2 weeks by VZV encephalitis and 2 months later by ischemic optic neuropathy. Temporal artery biopsy was histopathologically negative for GCA, but contained VZV antigen and VZV DNA in multiple non-contiguous (skip) areas. The collective clinical and laboratory findings revealed a remarkably close temporal association of zoster, multifocal VZV vasculopathy with temporal artery infection, biopsy-negative VZV-positive GCA and VZV encephalitis. (C) 2014 Elsevier B.V. All rights reserved.

【 授权许可】

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