VZV multifocal vasculopathy with ischemic optic neuropathy, acute retinal necrosis and temporal artery infection in the absence of zoster rash

JOURNAL OF THE NEUROLOGICAL SCIENCES

卷:325

Article

Mathias, Marc¹  Nagel, Maria A.²  Khmeleva, Nelly²  Boyer, Philip J.³  Choe, Alexander²  Durairaj, Vikram D.¹  Bennett, Jeffrey L.^1,2  Mandava, Naresh¹  Gilden, Don^2,4 

[1] Univ Colorado, Sch Med, Dept Ophthalmol, Aurora, CO USA

[2] Univ Colorado, Sch Med, Dept Neurol, Aurora, CO USA

[3] Univ Colorado, Sch Med, Dept Pathol, Aurora, CO USA

[4] Univ Colorado, Sch Med, Dept Microbiol, Aurora, CO USA

关键词: Varicella zoster virus;    Ischemic optic neuropathy;    Temporal arteritis;   

DOI  :  10.1016/j.jns.2012.12.021

来源: Elsevier

【 摘 要 】

We describe a 54-year-old diabetic woman who developed ischemic optic neuropathy followed by acute retinal necrosis and multiple areas of focal venous beading. Vitreous fluid contained amplifiable VZV DNA but not HSV-1, CMV or toxoplasma DNA. The clinical presentation was remarkable for jaw claudication and intermittent scalp pain, prompting a temporal artery biopsy that was pathologically negative for giant cell arteritis, but notable for VZV antigen. The current case adds to the clinical spectrum of multifocal VZV vasculopathy. The development of acute VZV retinal necrosis after ischemic optic neuropathy supports the notion that vasculitis is an important additional mechanism in the development of VZV retinal injury. (C) 2013 Elsevier B.V. All rights reserved.

【 授权许可】

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