Varicella zoster virus in the temporal artery of a patient with giant cell arteritis

JOURNAL OF THE NEUROLOGICAL SCIENCES

卷:335

Article

Nagel, Maria A.¹  Khmeleva, Nelly¹  Boyer, Philip J.²  Choe, Alexander¹  Bert, Robert³  Gilden, Don^1,4 

[1] Univ Colorado, Dept Neurol, Sch Med, Aurora, CO USA

[2] Univ Colorado, Dept Pathol, Sch Med, Aurora, CO USA

[3] Univ Louisville, Sch Med, Dept Radiol, Louisville, KY 40292 USA

[4] Univ Colorado, Dept Microbiol, Sch Med, Aurora, CO USA

关键词: Varicella zoster virus;    Temporal artery;    Giant cell arteritis;    Temporal arteritis;    Vasculopathy;    Stroke;   

DOI  :  10.1016/j.jns.2013.09.034

来源: Elsevier

【 摘 要 】

We recently detected varicella zoster virus (VZV) in the temporal arteries (TA) of 5/24 patients with clinically suspect giant cell arteritis (GCA) whose TAs were GCA-negative pathologically; in those GCA-negative, VZV + TAs, virus antigen predominated in the arterial adventitia, but without medial necrosis and multinucleated giant cells [1]. During our continuing search for VZV antigen in GCA-negative TAs, in the TA of one subject, we found abundant VZV antigen, as well as VZV DNA, in multiple regions (skip areas) of the TA spanning 350 mu m, as well as in skeletal muscle adjacent to the infected TA. Additional pathological analysis of sections adjacent to those containing viral antigen revealed inflammation involving the arterial media and abundant multinucleated giant cells characteristic of GCA. Detection of VZV in areas of the TA with pathological features of GCA warrants further correlative pathological-virological analysis of VZV in GCA. (c) 2013 Elsevier B.V. All rights reserved.

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