Design and synthesis of zinc protoporphyrin IX-adamantane/cyclodextrin/cellulose nanocrystals complexes for anticancer photodynamic therapy

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:41

Article

Ntoutoume, Gautier M. A. Ndong¹  Granet, Robert¹  Mbakidi, Jean-Pierre¹  Constantin, Elena¹  Bretin, Ludovic¹  Leger, David Y.¹  Liagre, Bertrand¹  Chaleix, Vincent¹  Bregier, Frederique¹  Sol, Vincent¹ 

[1] Univ Limoges, PEIRENE EA 7500, F-87060 Limoges, France

关键词: Cellulose nanocrystals;    Porphyrins;    Photodynamic therapy;    Colorectal cancer;    Nanoparticles;   

DOI  :  10.1016/j.bmcl.2021.128024

来源: Elsevier

【 摘 要 】

Two protoporphyrin IX (PpIX) adamantane derivatives were synthesized and then metallated with zinc. The ZnPpIX derivatives, exhibiting a high singlet oxygen quantum yield, were tested for their photodynamic activity against the HT-29 cell line. In order to enhance their water-solubility and their cellular bioavailability, these photosensitizers were encapsulated into the hydrophobic cavity of cyclodextrins (CD) previously attached to cellulose nanocrystals (CNCs) via electrostatic interactions. Under illumination, the encapsulated adamantanylporphyrins exerted an enhanced in vitro cytotoxicity, as compared with the corresponding free photosensitizers.

【 授权许可】

Free