Synthesis and biological evaluation of a new vitamin D2 analogue

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:22

Article

Gandara, Zoila¹  Perez, Manuel¹  Salomon, Debora G.²  Ferronato, Maria J.²  Fermento, Maria E.²  Curino, Alejandro C.²  Facchinetti, Maria M.²  Gomez, Generosa¹  Fall, Yagamare¹ 

[1] Univ Vigo, Fac Quim, Dept Quim Organ, Vigo 36200, Spain

[2] Consejo Nacl Invest Cient & Tecn, Lab Biol Canc, Inst Invest Bioquim Bahia Blanca, Ctr Cient Tecnol Bahia Blanca, RA-1033 Buenos Aires, DF, Argentina

关键词: Vitamin D-2 analogues;    Calcitriol;    Cancer;    Hypercalcemia;    Cellular proliferation;    Julia-Kocienski olefination;   

DOI  :  10.1016/j.bmcl.2012.07.095

来源: Elsevier

【 摘 要 】

A new vitamin D-2 analogue was synthesized using the Julia-Kocienski olefination. It has antiproliferative effects on cell lines from squamous cell carcinomas of colon and head and neck, but is also as hypercalcaemic as calcitriol in vivo. (C) 2012 Elsevier Ltd. All rights reserved.

【 授权许可】

Free