Targeting the homologous recombination pathway by small molecule modulators

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:24

Article

Huang, Fei¹  Mazin, Alexander V.¹ 

[1] Drexel Univ, Coll Med, Dept Biochem & Mol Biol, Philadelphia, PA 19102 USA

关键词: DNA repair;    DNA double stranded breaks;    RAD51;    RAD54;    BLM;    WRN;   

DOI  :  10.1016/j.bmcl.2014.04.088

来源: Elsevier

【 摘 要 】

During the last decade, the use of small molecule (MW <500 Da) compounds that modulate (inhibit or activate) important proteins of different biological pathways became widespread. Recently, the homologous recombination (FIR) pathway emerged as a target for such modulators. Development of small molecule modulators pursues two distinct but not mutually exclusive purposes: to create a research tool to study the activities or functions of proteins of interest and to produce drugs targeting specific pathologies. Here, we review the progress of small molecule development in the area of HR. (C) 2014 Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

【 授权许可】

Free