Synthesis and SAR of 3,5-diamino-piperidine derivatives: Novel antibacterial translation inhibitors as aminoglycoside mimetics

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:17

Article

Zhou, Yuefen ; Gregor, Vlad E. ; Ayida, Benjamin K. ; Winters, Geoffrey C. ; Sun, Zhongxiang ; Murphy, Douglas ; Haley, Greg ; Bailey, Dwight ; Froelich, Jamie M. ; Fish, Sarah ; Webber, Stephen E. ; Hermann, Thomas ; Wall, Daniel

关键词: aminoglycosides;    antibiotics;    translation inhibitors;    2-deoxy-streptamine;    ribosome;    decoding site;    3,5-diamino-piperidine;   

DOI  :  10.1016/j.bmcl.2006.12.024

来源: Elsevier

【 摘 要 】

Aminoglycoside antibiotics target an internal RNA loop within the bacterial ribosomal decoding site. Here, we describe the synthesis and SAR of novel 3,5-diamino-piperidine derivatives as aminoglycoside mimetics, and show they act as inhibitors of bacterial translation and growth. (c) 2006 Elsevier Ltd. All rights reserved.

【 授权许可】

Free