Antibacterial activity in serum of the 3,5-diamino-piperidine translation inhibitors

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:18

Article

Zhou, Yuefen¹  Chow, Chun¹  Murphy, Douglas E.¹  Sun, Zhongxiang¹  Bertolini, Thomas¹  Froelich, Jamie M.¹  Webber, Stephen E.¹  Hermann, Thomas¹  Wall, Daniel¹ 

[1] Anadys Pharmaceut Inc, San Diego, CA USA

关键词: aminoglycosides;    antibiotics;    translation inhibitors;    2-deoxy-streptamine;    ribosome;    decoding site;    3,5-diaminopiperidine;   

DOI  :  10.1016/j.bmcl.2008.04.023

来源: Elsevier

【 摘 要 】

Translation inhibitors of the 3,5-diamino-piperidine series act as aminoglycoside mimetics that inhibit bacterial growth. Here we show antibacterial SAR in the presence and absence of serum with a particular focus toward Pseudomonas aeruginosa. (C) 2008 Elsevier Ltd. All rights reserved.

【 授权许可】

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