Design and synthesis of new vancomycin derivatives

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:24

Article

Gu, Wen¹  Chen, Bei¹  Ge, Min^1,2 

[1] Nanjing Univ Technol, Coll Biotechnol & Pharmaceut Engn, Nanjing 210009, Peoples R China

[2] Acesys PharmaTech Inc, Nanjing 210009, Peoples R China

关键词: Anti-bacterial;    Vancomycin;    Synthesis;   

DOI  :  10.1016/j.bmcl.2014.03.093

来源: Elsevier

【 摘 要 】

A set of vancomycin derivatives with lipid chain attached via a glyceric acid linker was designed and synthesized. A concise synthesis towards these derivatives was developed and the IC(50)s of these new lipoglycopeptides were tested. Some of them showed very potent activity against both vancomycin sensitive and resistant strains. (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

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