Reduced antioxidant enzyme activity in brains of mice transgenic for human presenilin-1 with single or multiple mutations

NEUROSCIENCE LETTERS

卷:292

Article

Leutner, S ; Czech, C ; Schindowski, K ; Touchet, N ; Eckert, A ; Müller, WE

关键词: Alzheimer's disease;    reactive oxygen species;    presenilin;    superoxide dismutase;    glutathione reductase;    lipid peroxidation;   

DOI  :  10.1016/S0304-3940(00)01449-X

来源: Elsevier

【 摘 要 】

Alzheimer's disease-related mutations in the presenilin-1 gene (PS1) are leading to an elevated production of neurotoxic beta-amyloid 1-42 and may additionally enhance oxidative stress. Here, we provide in vivo evidence indicating that brains of transgenic mice expressing different human Alzheimer-linked PS1 mutations exhibit a reduced activity of two antioxidant enzymes. For this purpose, mice transgenic for human PS1 and for single and multiple PS1 mutations were generated. Mice with multiple PS1 mutations showed a significantly decreased activity of the antioxidant enzymes Cu/Zn superoxide dismutase and glutathione reductase already at an age of 3-4 months. As expected, this effect was less pronounced for the mice with a single PS1 mutation. By contrast, animals bearing normal human PS1 showed significantly elevated enzyme activities relative to non-transgenic littermate controls. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

【 授权许可】

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