A dynamic network perspective of chronic pain

NEUROSCIENCE LETTERS

卷:520

Review

Farmer, Melissa A.¹  Baliki, Marwan N.¹  Apkarian, A. Vania^1,2,3 

[1] Northwestern Univ, Dept Physiol, Feinberg Sch Med, Chicago, IL 60611 USA

[2] Northwestern Univ, Dept Anesthesia, Feinberg Sch Med, Chicago, IL 60611 USA

[3] Northwestern Univ, Dept Surg, Feinberg Sch Med, Chicago, IL 60611 USA

关键词: Chronic pain;    Functional magnetic resonance imaging;    Network;    Diffusion tensor imaging;    Neuroplasticity;    Learning;   

DOI  :  10.1016/j.neulet.2012.05.001

来源: Elsevier

【 摘 要 】

We briefly summarize recent advances regarding brain functional representation of chronic pain, reorganization of resting state brain activity, and of brain anatomy with chronic pain. Based on these observations and recent theoretical advances regarding network architecture properties, we develop a general concept of the dynamic interplay between anatomy and function as the brain progresses into persistent pain, and outline the role of mesolimbic learning mechanisms that are likely involved in maintenance of chronic pain. (c) 2012 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free