Multisite, multimodal neuroimaging of chronic urological pelvic pain: Methodology of the MAPP Research Network

NeuroImage: Clinical

卷:12

Timothy J. Ness¹  Daniel J. Clauw²  Richard E. Harris²  Cody Ashe-McNalley³  Jeffry R. Alger⁴  Sean C. Mackey⁵  Kevin A. Johnson⁵  Lejian Huang⁶  Melissa Farmer⁶  A. Vania Apkarian⁶  Davis C. Woodworth⁷  Benjamin M. Ellingson⁷  Todd B. Parrish⁸  Gary H. Glover⁹  Jan den Hollander¹⁰  Georg Deutsch¹¹  Chris Mullins¹²  John W. Kusek¹²  Emeran A. Mayer¹³  Jennifer S. Labus¹³ 

[1] Department of Anesthesiology, University of Alabama, Birmingham, AL, USA;

[2] Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA;

[3] Department of Internal Medicine, David Geffen School of Medicine at UCLA, USA;

[4] Department of Neurology, David Geffen School of Medicine at UCLA, USA;

[5] Department of Neurology, Stanford University, Palo Alto, CA, USA;

[6] Department of Physiology, Feinberg School of Medicine, Northwestern University, 300 E. Superior St., Chicago, IL 60611, USA;

[7] Department of Radiological Sciences, David Geffen School of Medicine at UCLA, USA;

[8] Department of Radiology, Northwestern University, Chicago, IL, USA;

[9] Department of Radiology, Stanford University, Palo Alto, CA, USA;

[10] Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA;

[11] Department of Radiology, University of Alabama, Birmingham, AL, USA;

[12] Division of Kidney, Urologic, and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA;

[13] UCLA Brain Research Institute, David Geffen School of Medicine at UCLA, USA;

关键词: Urologic chronic pelvic pain syndromes;    Brain;    Magnetic resonance imaging;    Functional magnetic resonance imaging;    Diffusion tensor imaging;    DTI;    TransMAPP;   

DOI  :  10.1016/j.nicl.2015.12.009

来源: DOAJ

【 摘 要 】

The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network is an ongoing multi-center collaborative research group established to conduct integrated studies in participants with urologic chronic pelvic pain syndrome (UCPPS). The goal of these investigations is to provide new insights into the etiology, natural history, clinical, demographic and behavioral characteristics, search for new and evaluate candidate biomarkers, systematically test for contributions of infectious agents to symptoms, and conduct animal studies to understand underlying mechanisms for UCPPS. Study participants were enrolled in a one-year observational study and evaluated through a multisite, collaborative neuroimaging study to evaluate the association between UCPPS and brain structure and function. 3D T1-weighted structural images, resting-state fMRI, and high angular resolution diffusion MRI were acquired in five participating MAPP Network sites using 8 separate MRI hardware and software configurations. We describe the neuroimaging methods and procedures used to scan participants, the challenges encountered in obtaining data from multiple sites with different equipment/software, and our efforts to minimize site-to-site variation.

【 授权许可】

Unknown