Progesterone, compared to medroxyprogesterone acetate, to C57BL/6, but not 5α-reductase mutant, mice enhances object recognition and placement memory and is associated with higher BDNF levels in the hippocampus and cortex

NEUROSCIENCE LETTERS

卷:551

Article

Frye, Cheryl A.^1,2,3,4,5  Koonce, Carolyn J.^1,4,5  Walf, Alicia A.^1,4,5 

[1] SUNY Albany, Dept Psychol, Albany, NY 12222 USA

[2] SUNY Albany, Ctr Neurosci, Albany, NY 12222 USA

[3] Univ Alaska, Dept Chem, Fairbanks, AK 99775 USA

[4] Univ Alaska, Inst Art Biol, Fairbanks, AK 99775 USA

[5] Univ Alaska, Alaska IDeA Network Biomed Excellence INBRE, Fairbanks, AK 99775 USA

关键词: Cognition;    Learning;    Memory;    Neurosteroids;    Hormone replacement therapy;    Brain derived neurotrophic factor (BDNF);   

DOI  :  10.1016/j.neulet.2013.07.002

来源: Elsevier

【 摘 要 】

Progesterone (P-4) may influence cognition in part through actions of its 5 alpha-reduced metabolite, allopregnanolone. Ovariectomized mice that were C57BL/6 wildtype (WT), or deficient in the 5 alpha-reductase Type 1 enzyme (5 alpha-reductase knockout; 5 alpha RKO), were administered vehicle, P-4, allopregnanolone, or medroxyprogesterone acetate (MPA) after training in the object recognition or placement tasks. WT mice administered P-4 or allopregnanolone performed significantly better in the object recognition and placement tasks than did WT mice administered vehicle or MPA. 5 alpha RKO mice administered allopregnanolone, but not P-4, MPA, or vehicle showed enhanced performance in the object recognition and placement tasks. Levels of brain-derived neurotrophic factor (BDNF) in the prefrontal cortex and hippocampus were lowest among mice administered MPA. Thus, some of P(4)s effects to enhance cognitive performance may be incumbent upon its 5 alpha-reduction. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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