Neurological issues in children with COVID-19

NEUROSCIENCE LETTERS

卷:743

Article

Lin, Jieru E.^1,2  Asfour, Arsenoi^1,2  Sewell, Taylor B.³  Hooe, Benjamin³  Pryce, Patrice³  Earley, Chelsea^1,2  Shen, Min Ye^1,2  Kerner-Rossi, Mallory^1,2  Thakur, Kiran T.⁴  Vargas, Wendy S.¹  Silver, Wendy G.¹  Geneslaw, Andrew S.³ 

[1] Columbia Univ, Dept Neurol, Div Child Neurol, Irving Med Ctr, New York, NY 10032 USA

[2] Columbia Univ, Morgan Stanley Childrens Hosp, Dept Pediat, Irving Med Ctr, New York, NY 10032 USA

[3] Columbia Univ, Div Pediat Crit Care & Hosp Med, Dept Pediat, Irving Med Ctr, New York, NY 10032 USA

[4] Columbia Univ, Dept Neurol, Irving Med Ctr, New York, NY 10032 USA

关键词: COVID-19;    Pediatrics;    Multisystem inflammatory syndrome in children (MIS-C);    SARS-CoV-2;   

DOI  :  10.1016/j.neulet.2020.135567

来源: Elsevier

【 摘 要 】

Coronavirus disease 2019 (COVID-19) usually leads to a mild infectious disease course in children, but serious complications may occur in conjunction with both acute infection and associated phenomena such as the multisystem inflammatory syndrome in children (MIS-C). Neurological symptoms, which have been predominantly reported in adults, range from mild headache to seizure, peripheral neuropathy, stroke, demyelinating disorders, and encephalopathy. Similar to respiratory and cardiac manifestations of COVID-19, neurological complications present differently based on age and underlying comorbidities. This review provides a concise overview of the neurological conditions seen in the context of COVID-19, as well as potential mechanisms and long-term implications of COVID-19 in the pediatric population from literature reviews and primary data collected at NewYork-Presbyterian Morgan Stanley Children's Hospital.

【 授权许可】

Free