Anxiety-like behaviors in mice lacking GIT2

NEUROSCIENCE LETTERS

卷:451

Article

Schmalzigaug, Robert¹  Rodriguiz, Ramona M.^2,3  Phillips, Lindsey E.^2,3  Davidson, Collin E.¹  Wetsel, William C.^2,3  Premont, Richard T.¹ 

[1] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27710 USA

[3] Duke Univ, Med Ctr, Mouse Behav & Neuroendocrine Anal Core Facil, Durham, NC 27710 USA

关键词: GIT2;    Knockout mice;    Anxiety/mood regulation;   

DOI  :  10.1016/j.neulet.2008.12.034

来源: Elsevier

【 摘 要 】

G protein-coupled receptor kinase-interactor 2 (GM) is a signaling scaffold protein that also functions as GTPase-activating protein (GAPS) for ADP-ribosylation factor (Arf) small GTP-binding proteins. GIT2 has been implicated in the regulation of G protein-coupled receptor trafficking and cell adhesion and migration. To evaluate possible neurobehavioral functions of GIT2 in vivo, we evaluated CIT2-knockout (KO) mice for abnormalities in emotionality and mood. Male and female GIT2-KO mice presented with anxiety-like behaviors in the zero-maze and light-dark emergence tests. Immobility times in tail suspension were reduced in GIT2-KO males, but were normal in GIT2-KO females. Hence, GIT2-KO mice display anxiety-like behavior in an absence of depressive-like responses. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free