Voxel-based assessment of gray and white matter volumes in Alzheimer's disease

NEUROSCIENCE LETTERS

卷:468

Article

Guo, Xiaojuan^2,3  Wang, Zhiqun⁴  Lic, Kuncheng⁴  Li, Ziyi²  Qi, Zhigang⁴  Jin, Zhen⁵  Yao, Li^2,3  Chen, Kewei¹ 

[1] Banner Good Samaritan PET Ctr, Phoenix, AZ 85006 USA

[2] Beijing Normal Univ, Coll Informat Sci & Technol, Beijing 100875, Peoples R China

[3] Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China

[4] Xuanwu Hosp Capital Med Univ, Dept Radiol, Beijing, Peoples R China

[5] Beijing 306 Hosp, Lab Magnet Resonance Imaging, Beijing, Peoples R China

关键词: Alzheimer's disease;    Gray matter;    Magnetic resonance imaging;    Voxel-based morphometry;    White matter;   

DOI  :  10.1016/j.neulet.2009.10.086

来源: Elsevier

【 摘 要 】

Using the study-specific templates and optimized voxel-based morphometry (VBM), this study investigated abnormalities in gray and white matter to provide depiction of the concurrent structural changes in 13 patients with Alzheimer's disease (AD) compared with 14 age- and sex-matched normal controls. Consistent with previous studies, patients with AD exhibited significant gray matter volume reductions mainly in the hippocampus, parahippocampal gyrus, insula, superior/middle temporal gyrus, thalamus, cingulate gyrus, and superior/inferior parietal lobule. In addition, white matter volume reductions were found predominately in the temporal lobe, corpus callosum, and inferior longitudinal fasciculus. Furthermore, a number of additional white matter regions such as precentral gyrus, cingulate fasciculus, superior and inferior frontal gyrus, and sub-gyral in parietal lobe were also affected. The pattern of gray and white matter volume reductions helps us understand the underlying pathologic mechanisms in AD and potentially can be used as an imaging marker for the studies of AD in the future. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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