Cortically evoked potentials in the human subthalamic nucleus

NEUROSCIENCE LETTERS

卷:539

Article

Zwartjes, Daphne G. M.¹  Janssen, Marcus L. F.^2,3,6  Heida, Tjitske¹  Van Kranen-Mastenbroek, Vivianne⁴  Bour, Lo J.⁷  Temel, Yasin^2,5,6  Visser-Vandewalle, Veerle⁸  Veltink, Peter H.¹ 

[1] Univ Twente, MIRA Inst Biomed Engn & Tech Med, Biomed Signals & Syst Grp, NL-7500 AE Enschede, Netherlands

[2] Maastricht Univ, Med Ctr, Dept Neurosci, Maastricht, Netherlands

[3] Maastricht Univ, Med Ctr, Dept Neurol, Maastricht, Netherlands

[4] Maastricht Univ, Med Ctr, Dept Neurophysiol, Maastricht, Netherlands

[5] Maastricht Univ, Med Ctr, Dept Neurosurg, Maastricht, Netherlands

[6] European Grad Sch Neurosci EURON, Maastricht, Netherlands

[7] Univ Amsterdam, Acad Med Ctr, Dept Neurol Clin Neurophysiol, NL-1105 AZ Amsterdam, Netherlands

[8] Univ Cologne, Dept Stereotact & Funct Neurosurg, D-50931 Cologne, Germany

关键词: Subthalamic nucleus;    Deep brain stimulation;    Parkinson's disease;    Motor cortex stimulation;    Local field potential;   

DOI  :  10.1016/j.neulet.2013.01.036

来源: Elsevier

【 摘 要 】

Deep brain stimulation (DES) of the subthalamic nucleus (STN) alleviates motor symptoms in Parkinson's disease (PD) patients. However, in a substantial number of patients the beneficial effects of STN DBS are overshadowed by psychiatric side effects. We hypothesize that stimulation of the STN motor area will provide the optimal effect on the motor symptoms without inducing these side effects, and expect that motor cortex stimulation (MCS) evokes a spatially specific response within the STN, which identifies the STN motor area. We previously showed that MCS evokes responses in the unit activity specifically within certain areas of the STN. Unit activity is generally considered a measure of the output activity. To gain more insight into the neuronal input into the STN, we describe the results of cortically evoked subthalamic local field potentials (LFPs). We show that the cortically evoked LFPs follow a certain temporal and spatial pattern. The significant peaks of the evoked LFPs coincide with the timing of some of the inhibitions and excitations present in the unit responses. The spatial resolution of responses measured in the LFP to MCS is not high enough to identify the STN motor region. However, we believe that optimizing targeting techniques and the development of novel DBS electrodes will improve STN DBS therapy for PD patients. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free