Weekend Ecstasy use disrupts memory in rats

NEUROSCIENCE LETTERS

卷:549

Article

McAleer, Leah M.¹  Schallert, Timothy^2,3  Duvauchelle, Christine L.^1,3 

[1] Univ Texas Austin, Coll Pharm, Div Pharmacol & Toxicol, Austin, TX 78712 USA

[2] Univ Texas Austin, Dept Psychol, Austin, TX 78712 USA

[3] Univ Texas Austin, Waggoner Ctr Alcohol & Addict Res, Austin, TX 78712 USA

关键词: Habituation;    MDMA;    Memory;    Rats;    Recognition;    Self-administration;   

DOI  :  10.1016/j.neulet.2013.05.030

来源: Elsevier

【 摘 要 】

3,4-Methylenedioxymethamphetamine (MDMA, or Ecstasy) is a popular recreational drug. However, its exposure is often limited to the weekends in a highly stimulating environment. The goal of this study was to investigate the behavioral domains of working and recognition memory within a model of weekend Ecstasy use. Rats self-administered MDMA during 2-h sessions on two consecutive days followed by five drug-free days. Coupling this intermittent dosing schedule with a novel object recognition task, we found non-spatial memory impaired after only two weekends of self-administered MDMA. Our findings suggest that MDMA at recreational use levels can disrupt memory processes. Published by Elsevier Ireland Ltd.

【 授权许可】

Free