Aberrant somatosensory phase synchronization in children with hemiplegic cerebral palsy

NEUROSCIENCE LETTERS

卷:762

Article

Song, Yanlong^1,2  Renoul, Emmanuelle^1,3  Acord, Stephanie¹  Johnson, Yvette R.^4,5,6  Marks, Warren¹  Alexandrakis, George²  Papadelis, Christos^1,2,5,6,7 

[1] Cook Childrens Hlth Care Syst, Jane & John Justin Neurosci Ctr, 1500 Cooper St, Ft Worth, TX 76104 USA

[2] Univ Texas Arlington, Dept Bioengn, Arlington, TX 76019 USA

[3] Univ Paris, Biomed Engn, Paris, France

[4] Cook Childrens Hlth Care Syst, Neonatol, NEST Dev Follow Up Ctr, Ft Worth, TX USA

[5] Texas Christian Univ, Dept Pediat, Ft Worth, TX 76129 USA

[6] Univ North Texas, Hlth Sci Ctr, Sch Med, Ft Worth, TX USA

[7] Harvard Med Sch, Div Newborn Med, Dept Med, Boston Childrens Hosp, Boston, MA 02115 USA

关键词: Cerebral palsy;    Functional connectivity;    Magnetoencephalography;    Phase synchronization;    Primary somatosensory cortex;    Secondary somatosensory cortex;   

DOI  :  10.1016/j.neulet.2021.136169

来源: Elsevier

【 摘 要 】

Children with hemiplegic cerebral palsy (HCP) often show disturbances of somatosensation. Despite extensive evidence of somatosensory deficits, neurophysiological alterations associated with somatosensory deficits in children with HCP have not been elucidated. Here, we aim to assess phase synchrony within and between contralateral primary (S1) and secondary (S2) somatosensory areas in children with HCP. Intra-regional and inter-regional phase synchronizations within and between S1 and S2 were estimated from somatosensory evoked fields (SEFs) in response to passive pneumatic stimulation of contralateral upper extremities and recorded with pediatric magnetoencephalography (MEG) in children with HCP and typically developing (TD) children. We found aberrant phase synchronizations within S1 and between S1 and S2 in both hemispheres in children with HCP. Specifically, the less-affected (LA) hemisphere demonstrated diminished phase synchronizations after the stimulus onset up to -120 ms compared to the more-affected (MA) hemisphere and the dominant hemisphere of TD children, while the MA hemisphere showed enhanced phase synchronizations after -100 ms compared to the LA hemisphere and the TD dominant hemisphere. Our findings indicate abnormal somatosensory functional connectivity in both hemispheres of children with HCP.

【 授权许可】

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