Disconnected neuromagnetic networks in children born very preterm

NeuroImage: Clinical

Sam M. Doesburg¹  Michelle AuCoin-Power²  Annette X. Ye²  Margot J. Taylor² 

[1] Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Vancouver, British Columbia, Canada;Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, Canada;

关键词: Magnetoencephalography;    Resting state;    Neural oscillations;    Functional connectivity;    Phase synchrony;    Very preterm;   

DOI  :  10.1016/j.nicl.2015.08.016

来源: DOAJ

【 摘 要 】

Many children born very preterm (≤32 weeks) experience significant cognitive difficulties, but the biological basis of such problems has not yet been determined. Functional MRI studies have implicated altered functional connectivity; however, little is known regarding the spatiotemporal organization of brain networks in this population. We provide the first examination of resting-state neuromagnetic connectivity mapped in brain space in school age children born very preterm. Thirty-four subjects (age range 7–12 years old), consisting of 17 very preterm-born children and 17 full-term born children were included. Very preterm-born children exhibited global decreases in inter-regional synchrony in all analysed frequency ranges, from theta (4–7 Hz) to high gamma (80–150 Hz; p < 0.01, corrected). These reductions were expressed in spatially and frequency specific brain networks (p < 0.0005, corrected). Our results demonstrate that mapping connectivity with high spatiotemporal resolution offers new insights into altered organization of neurophysiological networks which may contribute to the cognitive difficulties in this vulnerable population.

【 授权许可】

Unknown