Pinprick hypo- and hyperalgesia in diabetic rats: Can diet content affect experimental outcome?

NEUROSCIENCE LETTERS

卷:673

Article

Yadlapalli, Jai Shankar K.^1,4  Dogra, Navdeep^2,5  Walbaum, Anqi W.¹  Prather, Paul L.³  Crooks, Peter A.¹  Dobretsov, Maxim² 

[1] Univ Arkansas Med Sci, Coll Pharm, Dept Pharmaceut Sci, Little Rock, AR 72205 USA

[2] Univ Arkansas Med Sci, Coll Med, Dept Anesthesiol, Slot 515,4301 West Markham St, Little Rock, AR 72205 USA

[3] Univ Arkansas Med Sci, Coll Med, Dept Pharmacol & Toxicol, Little Rock, AR 72205 USA

[4] Lupin Pharmaceut Inc, Somerset, NJ 08873 USA

[5] Adv Spine & Pain Ctr, 9800 Baptist Hlth Dr,Ste 660, Little Rock, AR 72205 USA

关键词: Streptozotocin-induced diabetes;    Diabetic neuropathy;    Evoked pricking pain;    Hyperalgesia;    Hypoalgesia;   

DOI  :  10.1016/j.neulet.2018.02.054

来源: Elsevier

【 摘 要 】

Existing literature concerning the effect of experimentally-induced diabetes on pain thresholds in rodent models remains controversial. In this work, we describe a phenotypical switch from streptozotocin-induced pinprick hypoalgesia to hyperalgesia observed in the same laboratory, in the same strain of rats, obtained from the same vendor, and measured by the same technique carried out by the investigators. This switch was observed around January 2015, at the time when there was a change in the diet of rats at the Radley North Carolina Charles River facility. These data support the contention that diet may significantly modify disease progression, including progression of signs of diabetic neuropathy.

【 授权许可】

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