Immunomodulatory effects of black solo garlic (Allium sativum L.) on streptozotocin-induced diabetes in Wistar rats

Heliyon

Desiyani Nani¹  Saryono²  Atikah Proverawati²  Sarmoko³ 

[1] Corresponding author.;Nursing Department, Faculty of Health Sciences, University of Jenderal Soedirman, Dr. Soeparno Street Purwokerto 53123, Indonesia;Nutrition Department, Faculty of Health Sciences, University of Jenderal Soedirman, Dr. Soeparno Street Purwokerto 53123, Indonesia;

关键词: Allium sativum;    Black solo garlic;    Immunomodulator;    Interferon;    Interleukin;    Streptozotocin-induced diabetes;   

DOI  :  

来源: DOAJ

【 摘 要 】

Diabetes mellitus is a chronic disease that leads to different complications. Therefore, this study aims to investigate the immunomodulatory effects of the black solo garlic on streptozotocin (STZ)-induced diabetic rats. The Wistar rats were grouped into six groups of: normal control, negative control, treatment dose of 6.5 g/kg, 13.5 g/kg, and 26 g/kg body weight, and positive control glibenclamide. In addition to normal control, rats were induced with STZ on day 8–11. Also, steeping black solo garlic or glibenclamide was administered on the day 12–19. The experimental animals were sacrificed on day 20 and tumor necrosis factor (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β) and interferon gamma (IFN-γ) were measured using ELISA. The results showed that the administration of steeping black solo garlic significantly decreased levels of IL-1β, IL-6 and TNF-α as well as increased IFN-γ with the immunity of STZ-induced rats.

【 授权许可】

Unknown