Impaired glucose sensing by intrahepatic, muscarinic nerves for an insulin‐stimulated hepatic glucose uptake in streptozotocin‐diabetic rats

FEBS Letters

Scholtka, Bettina¹  Jungermann, Kurt¹  Stümpel, Frank¹ 

[1] Institut für Biochemie und Molekulare Zellbiologie, Georg-August-Universität, Humboldtallee 23, 37073 Göttingen, Germany

关键词: Bivascularly perfused rat liver;    Streptozotocin-induced diabetes;    Diabetic neuropathy;    Hepatic nerve;    Glucose metabolism;    HA;    hepatic artery;    IVC;    inferior vena cava;    PV;    protal vein;    SMA;    superior mesenteric artery;   

DOI  :  10.1016/S0014-5793(98)01121-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Insulin-induced net hepatic glucose uptake depends on the sensing by muscarinic, intrahepatic nerves of a glucose concentration gradient between portal vein and hepatic artery. The function of these intrahepatic nerves was examined in streptozotocin-diabetic rats. In the presence of the glucose gradient insulin induced net glucose uptake in isolated perfused livers from control and acutely diabetic but not from chronically diabetic animals. The neurotransmitter acetylcholine still mimicked the existence of the gradient, excluding a metabolic impairment of livers of chronically diabetic animals. The impairment of the intrahepatic nerves due to diabetic neuropathy could contribute to postprandial hyperglycemia in diabetes mellitus.

【 授权许可】

Unknown