Effects of antidyskinetic nicotine treatment on dopamine release in dorsal and ventral striatum

NEUROSCIENCE LETTERS

卷:672

Article

Leino, Sakari¹  Koski, Sini K.¹  Rannanpaa, Saara¹  Salminen, Outi¹ 

[1] Univ Helsinki, Fac Pharm, Div Pharmacol & Pharmacotherapy, FIN-00014 Helsinki, Finland

关键词: Parkinson's disease;    Levodopa;    Dyskinesia;    Nicotine;    Dopamine;   

DOI  :  10.1016/j.neulet.2018.02.042

来源: Elsevier

【 摘 要 】

The treatment of Parkinson's disease is often complicated by levodopa-induced dyskinesia (LID), and antidyskinetic treatment options are currently sparse. Nicotinic acetylcholine receptors have been suggested as potential targets for treatment of LID, as nicotinic agonists have been reported to alleviate LID in animal models. We aimed at the first independent replication of an antidyskinetic effect by nicotine using a mouse model of LID, and at investigation of its mechanisms by studying the release of [H-3]dopamine from synaptosomes prepared from the dorsal and ventral striatum. Chronic nicotine treatment in drinking water inhibited the development of LID in mice lesioned unilaterally with 6-hydroxydopamine and treated chronically with levodopa and benserazide. The antidyskinetic nicotine treatment had no effect on [H-3]dopamine release mediated by alpha 4 beta 2* nicotinic receptors, but decreased alpha 6 beta 2*-mediated [H-3]dopamine release in the lesioned dorsal striatum and the ventral striatum. In addition, nicotine treatment restored [H-3]dopamine release in the lesioned ventral striatum to intact levels. The results support a role for nicotinic receptors as drug targets for treatment of LID, and suggest that striatal presynaptic alpha 6 beta 2* receptors are important mediators of nicotine's antidyskinetic effect.

【 授权许可】

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