Interdependence of measures in Pavlovian conditioned freezing

NEUROSCIENCE LETTERS

卷:505

Article

Wood, Suzanne C.¹  Anagnostaras, Stephan G.^2,3 

[1] Columbia Univ, Dept Psychol, Learning Lab, New York, NY 10027 USA

[2] Univ Calif San Diego, Dept Psychol, Mol Cognit Lab, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Program Neurosci, La Jolla, CA 92093 USA

关键词: Pavlovian fear conditioning;    Classical conditioning;    Learning;    Memory;    Mice;   

DOI  :  10.1016/j.neulet.2011.10.006

来源: Elsevier

【 摘 要 】

Pavlovian conditioned freezing is an intensively utilized paradigm that has become a standard model of memory and cognition. Despite its widespread use, the interdependence among each measure commonly reported in fear conditioning studies has not been described. Using mice, we examine the relationship of each common freezing measure (Training Baseline, Post-Shock freezing, Contextual Fear, Tone Baseline, and Tone Fear), as well as baseline locomotor activity measures, to better understand the significance of each. Of particular interest, Post-Shock freezing appears to be a good measure of immediate contextual memory. In contrast, Tone Baseline freezing, as typically measured in a novel context, appears to be contaminated with multiple sources of fear. Finally, Contextual and Tone Fear show a weak interdependence. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free