Circadian waveform bifurcation, but not phase-shifting, leaves cued fear memory intact

PHYSIOLOGY & BEHAVIOR

卷:169

Article

Harrison, E. M.^1,2  Carmack, S. A.³  Block, C. L.⁴  Sun, J.^1,2  Anagnostaras, S. G.²  Gorman, M. R.^1,2 

[1] Univ San Diego, Ctr Circadian Biol, 9500 Gilman Dr, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Psychol, 9500 Gilman Dr, La Jolla, CA 92093 USA

[3] NIDA, Neurobiol Addict Sect, NIH, Baltimore, MD USA

[4] Duke Univ, Dept Psychol & Neurosci, 417 Chapel Dr, Durham, NC 27708 USA

关键词: Circadian;    Waveform;    Bifurcation;    Pavlovian fear conditioning;    Learning;    Memory;   

DOI  :  10.1016/j.physbeh.2016.11.033

来源: Elsevier

【 摘 要 】

In mammals, memory acquisition and retrieval can be affected by time of day, as well as by manipulations of the light/dark cycle. Under bifurcation, a manipulation of circadian waveform, two subjective days and nights are experimentally induced in rodents. We examined the effect of bifurcation on Pavlovian fear conditioning, a prominent model of learning and memory. Here we demonstrate that bifurcation of the circadian waveform produces a small deficit in acquisition, but not on retrieval of fear memory. In contrast, repeated phase-shifting in a simulated jet-lag protocol impairs retrieval of memory for cued fear. The results have implications for those attempting to adjust to shift-work or other challenging schedules. (C) 2016 Elsevier Inc. All rights reserved.

【 授权许可】

Free