The role of mitochondria in amyotrophic lateral sclerosis

NEUROSCIENCE LETTERS

卷:710

Review

Smith, Emma F.¹  Shaw, Pamela J.¹  De Vos, Kurt J.¹ 

[1] Univ Sheffield, Dept Neurosci, Sheffield Inst Translat Neurosci SITraN, Sheffield S10 2HQ, S Yorkshire, England

关键词: Amyothrophic lateral sclerosis;    Motor neuron disease;    Mitochondria;    Neurodegeneration;    Oxidative stress;    Mitophagy;    Axonal transport;    Oxidative phosphorylation;    Apoptosis;   

DOI  :  10.1016/j.neulet.2017.06.052

来源: Elsevier

【 摘 要 】

Mitochondria are unique organelles that are essential for a variety of cellular processes including energy metabolism, calcium homeostasis, lipid biosynthesis, and apoptosis. Mitochondrial dysfunction is a prevalent feature of many neurodegenerative diseases including motor neuron disorders such as amyotrophic lateral sclerosis (ALS). Disruption of mitochondrial structure, dynamics, bioenergetics and calcium buffering has been extensively reported in ALS patients and model systems and has been suggested to be directly involved in disease pathogenesis. Here we review the alterations in mitochondrial parameters in ALS and examine the common pathways to dysfunction. (C) 2017 The Authors. Published by Elsevier Ireland Ltd.

【 授权许可】

Free