A thermodynamic framework for modelling membrane transporters

JOURNAL OF THEORETICAL BIOLOGY

卷:481

Article

Pan, Michael^1,2  Gawthrop, Peter J.^1,2  Tran, Kenneth³  Cursons, Joseph^4,5  Crampin, Edmund J.^1,2,6,7 

[1] Univ Melbourne, Melbourne Sch Engn, Syst Biol Lab, Sch Math & Stat, Parkville, Vic 3010, Australia

[2] Univ Melbourne, Melbourne Sch Engn, Dept Biomed Engn, Parkville, Vic 3010, Australia

[3] Univ Auckland, Auckland Bioengn Inst, Auckland, New Zealand

[4] Walter & Eliza Hall Inst Med Res, Bioinformat Div, Parkville, Vic 3052, Australia

[5] Univ Melbourne, Sch Med, Dept Med Biol, Parkville, Vic 3010, Australia

[6] Univ Melbourne, Fac Med Dent & Hlth Sci, Sch Med, Parkville, Vic 3010, Australia

[7] Univ Melbourne, ARC Ctr Excellence Convergent Bionano Sci & Techn, Melbourne Sch Engn, Parkville, Vic 3010, Australia

关键词: Bond graph;    Biochemistry;    Chemical reaction network;    Biomedical engineering;    Systems biology;   

DOI  :  10.1016/j.jtbi.2018.09.034

来源: Elsevier

【 摘 要 】

Membrane transporters contribute to the regulation of the internal environment of cells by translocating substrates across cell membranes. Like all physical systems, the behaviour of membrane transporters is constrained by the laws of thermodynamics. However, many mathematical models of transporters, especially those incorporated into whole-cell models, are not thermodynamically consistent, leading to unrealistic behaviour. In this paper we use a physics-based modelling framework, in which the transfer of energy is explicitly accounted for, to develop thermodynamically consistent models of transporters. We then apply this methodology to model two specific transporters: the cardiac sarcoplasmic/endoplasmic Ca2+ ATPase (SERCA) and the cardiac Na+/K+ ATPase. (C) 2018 Elsevier Ltd. All rights reserved.

【 授权许可】

Free