Aging of marrow stromal (skeletal) stem cells and their contribution to age-related bone loss

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1792

Article; Proceedings Paper

Bellantuono, Ilaria¹  Aldahmash, Abdullah²  Kassem, Moustapha^2,3,4 

[1] Univ Sheffield, Acad Unit Bone Biol, Fac Med Dent & Hlth, Sch Med, Sheffield S10 2RX, S Yorkshire, England

[2] King Saud Univ, Stem Cell Unit, Dept Anat, Riyadh, Saudi Arabia

[3] Odense Univ Hosp, Univ Dept Endocrinol, DK-5000 Odense, Denmark

[4] Ctr Med Biotechnol, DK-5000 Odense, Denmark

关键词: Mesenchymal stem cell;    Ageing;    Marrow stromal cell;    Senescence;    Telomeres Notch;   

DOI  :  10.1016/j.bbadis.2009.01.008

来源: Elsevier

【 摘 要 】

Marrow stromal cells (MSC) are thought to be stem cells with osteogenic potential and therefore responsible for the repair and maintenance of the skeleton. Age related bone loss is one of the most prevalent diseases in the elder population. It is controversial whether MSC undergo a process of aging in vivo, leading to decreased ability to form and maintain bone homeostasis with age. In this review we summarize evidence of MSC involvement in age related bone loss and suggest new emerging targets for intervention. Crown Copyright (C) 2009 Published by Elsevier B.V. All rights reserved.

【 授权许可】

Free