Viruses and the nucleolus: The fatal attraction

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1842

Review

Salvetti, Anna¹ 

[1] Univ Lyon, Ecole Normale Super Lyon, CNRS UMR5308, CIRI,Int Ctr Infectiol Res,Inserm U1111, F-69365 Lyon, France

关键词: Positive-strand RNA virus;    Herpes virus;    Nucleolar protein;    Apoptosis;    Angiogenesis;   

DOI  :  10.1016/j.bbadis.2013.12.010

来源: Elsevier

【 摘 要 】

Viruses are small obligatory parasites and as a consequence, they have developed sophisticated strategies to exploit the host cell's functions to create an environment that favors their own replication. A common feature of most - if not all - families of human and non-human viruses concerns their interaction with the nucleolus. The nucleolus is a multifunctional nuclear domain, which, in addition to its well-known role in ribosome biogenesis, plays several crucial other functions. Viral infection induces important nucleolar alterations. Indeed, during viral infection numerous viral components localize in nucleoli, while various host nucleolar proteins are redistributed in other cell compartments or are modified, and non-nucleolar cellular proteins reach the nucleolus. This review highlights the interactions reported between the nucleolus and some human or animal viral families able to establish a latent or productive infection, selected on the basis of their known interactions with the nucleolus and the nucleolar activities, and their links with virus replication and/or pathogenesis. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease. (C) 2014 Elsevier B.V. All rights reserved.

【 授权许可】

Free