Sobemovirus genome appears to encode a serine protease related to cysteine proteases of picornaviruses

FEBS Letters

Gorbalenya, Alexander E.¹  Koonin, Eugene V.¹  Blinov, Vladimir M.¹  Donchenko, Alexei P.¹ 

[1] Institute of Poliomyelitis and Viral Encephalitides, USSR Academy of Medical Sciences, 142782 Moscow Region, USSR

关键词: Amino acid sequence comparison;    Serine protease;    Cysteine protease;    Positive-strand RNA virus;    Enzyme evolution;    SBMV;    southern bean mosaic virus;    RV89;    rhinovirus type 89;    PV1;    poliovirus type 1;    EMCV;    encephalomyocarditis virus (picornaviruses);    CPMV;    cowpea mosaic virus (comovirus);    TVMV;    tobacco vein mottling virus (potyvirus). THR;    thrombin;    CHT;    chymotrypsin;    TRP;    trypsin;    PTRPG;    protrypsinogen;    SGPA;    Streptomyces griseus protease A;    ALP;    bacterial α-lytic protease (serine proteases);    3CPPro;    picornaviral 3C protease;   

DOI  :  10.1016/0014-5793(88)80039-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A putative serine protease was identified among non-structural proteins of southern bean mosaic virus (SBMV) by sequence comparison with cellular and viral proteases. The predicted SBMV proteased is played a significant similarity to cysteine proteases of picornaviruses, providing a possible evolutionary link between the two enzyme classes. It is suggested that SBMV follows the general expression strategy characteristic of other positive-strand RNA viruses containing 5′-terminal covalently linked proteins (VPg), i.e. generation of functional proteins by polyprotein processing.

【 授权许可】

Unknown