Animal models reveal role for tau phosphorylation in human disease

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1802

Article

Goetz, Juergen¹  Gladbach, Amadeus¹  Pennanen, Luis²  van Eersel, Janet¹  Schild, Andreas³  Ittner, Lars M.¹ 

[1] Univ Sydney, Brain & Mind Res Inst, Alzheimers & Parkinsons Dis Lab, Camperdown, NSW 2050, Australia

[2] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94158 USA

[3] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Human Genet Res, Boston, MA USA

关键词: Alzheimer's disease;    Amyloid;    Drosophila;    Frontotemporal dementia;    Kinase;    Mice;    Nematode;    Phosphatase;    Phosphorylation;    Tau;    Transgenic;   

DOI  :  10.1016/j.bbadis.2009.09.008

来源: Elsevier

【 摘 要 】

Many proteins that are implicated in human disease are posttranslationally modified. This includes the microtubule-associated protein tau that is deposited in a hyperphosphorylated form in brains of Alzheimer's disease patients. The focus of this review article is on the physiological and pathological phosphorylation of tau; the relevance of aberrant phosphorylation for disease; the role of kinases and phosphatases in this process; its modeling in transgenic mice, flies, and worms; and implications of phosphorylation for therapeutic intervention. (C) 2009 Elsevier B.V. All rights reserved.

【 授权许可】

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