Cholangiocytes: Cell transplantation

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1864

Article

Ridola, Lorenzo¹  Bragazzi, Maria Consiglia¹  Cardinale, Vincenzo¹  Carpino, Guido²  Gaudio, Eugenio³  Alvaro, Domenico⁴ 

[1] Sapienza Univ Rome, Dept Medicosurg Sci & Biotechnol, Polo Pontino, Rome, Italy

[2] Univ Rome Foro Italico, Dept Movement Human & Hlth Sci, Div Hlth Sci, Rome, Italy

[3] Sapienza Univ Rome, Dept Anat Histol Forens Med & Orthoped Sci, Rome, Italy

[4] Sapienza Univ Rome, Dept Internal Med & Med Specialties, Div Gastroenterol, Viale Policlin 151, I-00161 Rome, Italy

关键词: Liver cell therapy;    Hepatic stem cells;    Biliary tree stem cells;    Hepatocytes;    Mesenchymal stem cells;    Grafting;   

DOI  :  10.1016/j.bbadis.2017.07.016

来源: Elsevier

【 摘 要 】

Background: Due to significant limitations to the access to orthotropic liver transplantation, cell therapies for liver diseases have gained large interest worldwide. Scope of review: To revise current literature dealing with cell therapy for liver diseases. We discussed the advantages and pitfalls of the different cell sources tested so far in clinical trials and the rationale underlying the potential benefits of transplantation of human biliary tree stem cells (hBTSCs). Major conclusions: Transplantation of adult hepatocytes showed transient benefits but requires immune-suppression that is a major pitfall in patients with advanced liver diseases. Mesenchymal stem cells and hematopoietic stem cells transplanted into patients with liver diseases are not able to replace resident hepatocytes but rather they target autoimmune or inflammatory processes into the liver. Stem cells isolated from fetal or adult liver have been recently proposed as alternative cell sources for advanced liver cirrhosis and metabolic liver disease. We demonstrated the presence of multipotent cells expressing a variety of endodermal stem cell markers in (peri)-biliary glands of bile ducts in fetal or adult human tissues, and in crypts of gallbladder epithelium. In the first cirrhotic patients treated in our center with biliary tree stem cell therapy, we registered no adverse event but significant benefits.

【 授权许可】

Free