Dynamics of diabetes and obesity: Epidemiological perspective

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1863

Review

Boles, Annette¹  Kandimalla, Ramesh²  Reddy, P. Hemachandra^{1,2,3,4,5,6,7,8} 

[1] Community Outreach & Educ, 6630 S Quaker Ave,Suite E, Lubbock, TX 79413 USA

[2] Texas Tech Univ, Hlth Sci Ctr, Garrison Inst Aging, 3601 4th St,MS 9424, Lubbock, TX 79430 USA

[3] Texas Tech Univ, Hlth Sci Ctr, Dept Cell Biol & Biochem, 3601 4th St, Lubbock, TX 79430 USA

[4] Texas Tech Univ, Hlth Sci Ctr, Dept Pharmacol & Neurosci, 3601 4th St, Lubbock, TX 79430 USA

[5] Texas Tech Univ, Hlth Sci Ctr, Dept Neurol, 3601 4th St, Lubbock, TX 79430 USA

[6] Texas Tech Univ, Hlth Sci Ctr, Speech Dept, 3601 4th St, Lubbock, TX 79430 USA

[7] Texas Tech Univ, Hlth Sci Ctr, Language & Hearing Sci Dept, 3601 4th St, Lubbock, TX 79430 USA

[8] Dept Publ Hlth, 3601 4th St,MS 9424, Lubbock, TX 79430 USA

关键词: Alzheimer's disease;    Diabetes;    Obesity;    FTO;   

DOI  :  10.1016/j.bbadis.2017.01.016

来源: Elsevier

【 摘 要 】

The purpose of this review article is to understand the current literature on obesity, diabetes and therapeutic avenues across the world. Diabetes is a chronic lifestyle condition that affects millions of people worldwide and it is a major health concern in our society. Diabetes and obesity are associated with various conditions, including non modifiable and modifiable risk factors. Early detectable markers are not well established to detect pre-diabetes and as a result, it becomes diabetes. Several published epidemiological studies were assessed and the findings were summarized. Resources from published studies were used to identify criteria used for pre-diabetes, the role of diet in pre-diabetics and potential risks and characteristics associated with pre-diabetes. Preventive strategies are needed to combat diabetes. Individuals diagnosed with pre-diabetes need detailed education, need to fully understand the risk factors and have the ability to manage diabetes. Interventions exist that include chronic disease self-management programs, lifestyle interventions and pharmacological strategies. Obesity plays a large role in causing pre-diabetes and diabetes. Critical analysis of existing epidemiological research data suggests that additional research is needed to determine the efficacy of interventions. This article is part of a Special Issue entitled: Oxidative Stress and Mitochondrial Quality in Diabetes/Obesity and Critical Illness Spectrum of Diseases edited by P. Hemachandra Reddy. (C) 2017 Elsevier B.V. All rights reserved.

【 授权许可】

Free