The use of PIB-PET as a dual pathological and functional biomarker in AD

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1822

Article

Engler, Henry^2,3,4,5  Blomquist, Gunnar⁶  Langstrom, Bengt⁷  Nordberg, Agneta^1,8 

[1] Karolinska Inst, Karolinska Univ Hosp Huddinge, Alzheimer Neurobiol Ctr, Dept Neurobiol Care Sci & Soc, S-14186 Stockholm, Sweden

[2] Uppsala Univ, Dept Med Sci, SE-75181 Uppsala, Sweden

[3] Univ Hosp, Dept Nucl Med, Montevideo, Uruguay

[4] Univ Republica, Ctr Nucl Res, Montevideo, Uruguay

[5] Uruguayan Ctr Mol Imaging, Montevideo, Uruguay

[6] Uppsala Univ, Dept Oncol Radiol & Clin Immunol, SE-75185 Uppsala, Sweden

[7] Uppsala Univ, Dept Biochem & Organ Chem, SE-75185 Uppsala, Sweden

[8] Karolinska Univ Hosp Huddinge, Dept Geriatr Med, Stockholm, Sweden

关键词: PIB;    Positron emission tomography (PET);    Alzheimer's disease (AD);    Cerebral blood flow;    Cerebral glucose metabolism;    Mild Cognitive Impairment (MCI);   

DOI  :  10.1016/j.bbadis.2011.11.006

来源: Elsevier

【 摘 要 】

Amyloid imaging with positron emission tomography (PET) is presently used in Alzheimer's disease (AD) research. In this study we investigated the possibility to use early frames (ePIB) of the PIB scans as a rough index of CBF by comparing normalised early PIB values with cerebral glucose metabolism (rCMRglc). PIB-PET and FDG-PET were performed in 37 AD patients, 21 subjects with mild cognitive impairment (MCI) and 6 healthy controls (HC). The patients were divided based on their PIB retention (amyloid load) as either PIB positive (PIB+) or PIB negative (PIB-). Data of the unidirectional influx K-1 from a subset of the subjects including 7 AD patients and 3 HC was used for correlative analysis. Data was analysed using regions of interest (ROI) analysis. A strong, positive correlation was observed across brain regions between K-1 and ePIB (r=0.70: p <= 0.001). The ePIB values were significantly lower in the posterior cingulate (p <= 0.001) and the parietal cortices (p = 0.002) in PIB+ subjects compared to PIB-, although the group difference were stronger for rCMRglc in cortical areas (p <= 0.001). Strong positive correlations between ePIB and rCMRglc were observed in all cortical regions analysed, especially in the posterior cingulate and parietal cortices (p <= 0.001). A single dynamic PIE-PET scan may provide information about pathological and functional changes (amyloidosis and impaired blood flow). This might be important for diagnosis of AD, enrichment of patients in clinical trials and evaluation of treatment effects. This article is part of a Special Issue entitled: Imaging Brain Aging and Neurodegenerative disease. (C) 2011 Elsevier B.V. All rights reserved.

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