Role of iron metabolism in heart failure: From iron deficiency to iron overload

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1865

Article

Zhang, Hao^1,2  Zhabyeyev, Pavel^1,2  Wang, Shaohua^2,3  Oudit, Gavin Y.^1,2 

[1] Dept Med, Div Cardiol, Edmonton, AB, Canada

[2] Mazankowski Alberta Heart Inst, Edmonton, AB, Canada

[3] Univ Alberta, Dept Surg, Div Cardiac Surg, Edmonton, AB, Canada

关键词: Heart failure;    Cardiomyopathy;    Hemochromatosis;    Iron deficiency;    Iron overload;    Iron metabolism;    Hepcidin;    Genetic regulation;    Mitochondrial function;   

DOI  :  10.1016/j.bbadis.2018.08.030

来源: Elsevier

【 摘 要 】

Iron metabolism is a balancing act, and biological systems have evolved exquisite regulatory mechanisms to maintain iron homeostasis. Iron metabolism disorders are widespread health problems on a global scale and range from iron deficiency to iron-overload. Both types of iron disorders are linked to heart failure. Iron play a fundamental role in mitochondrial function and various enzyme functions and iron deficiency has a particular negative impact on mitochondria function. Given the high-energy demand of the heart, iron deficiency has a particularly negative impact on heart function and exacerbates heart failure. Iron-overload can result from excessive gut absorption of iron or frequent use of blood transfusions and is typically seen in patients with congenital anemias, sickle cell anemia and beta-thalassemia major, or in patients with primary hemochromatosis. This review provides an overview of normal iron metabolism, mechanisms underlying development of iron disorders in relation to heart failure, including iron-overload cardiomyopathy, and clinical perspective on the treatment options for iron metabolism disorders.

【 授权许可】

Free