Non-coding RNA crosstalk with nuclear receptors in liver disease

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1867

Article

Wu, Jianguo^1,3  Nagy, Laura E.^1,2,3  Liangpunsakul, Suthat^4,5,6  Wang, Li⁷ 

[1] Cleveland Clin, Dept Inflammat & Immun, Lerner Res Inst, Cleveland, OH 44106 USA

[2] Cleveland Clin, Dept Gastroenterol & Hepatol, Lerner Res Inst, Cleveland, OH 44106 USA

[3] Case Western Reserve Univ, Dept Mol Med, Cleveland, OH 44106 USA

[4] Indiana Univ Sch Med, Dept Med, Div Gastroenterol & Hepatol, Indianapolis, IN 46202 USA

[5] Richard L Roudebush Vet Adm Med Ctr, Indianapolis, IN USA

[6] Indiana Univ Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USA

[7] Yale Univ, Dept Internal Med, Sect Digest Dis, New Haven, CT USA

关键词: ALD;    NAFLD;    NASH;    Hepatitis;    Cholestatic liver disease;    Liver cancer;    HCC;    Drug-induced liver injury;    Inflammation;    Fibrosis;    Steatosis;    Lipid metabolism;    Bile acids;   

DOI  :  10.1016/j.bbadis.2021.166083

来源: Elsevier

【 摘 要 】

The dysregulation of nuclear receptors (NRs) underlies the pathogenesis of a variety of liver disorders. Noncoding RNAs (ncRNAs) are defined as RNA molecules transcribed from DNA but not translated into proteins. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two types of ncRNAs that have been extensively studied for regulating gene expression during diverse cellular processes. NRs as therapeutic targets in liver disease have been exemplified by the successful application of their pharmacological ligands in clinics. MiRNAbased reagents or drugs are emerging as flagship products in clinical trials. Advancing our understanding of the crosstalk between NRs and ncRNAs is critical to the development of diagnostic and therapeutic strategies. This review summarizes recent findings on the reciprocal regulation between NRs and ncRNAs (mainly on miRNAs and lncRNAs) and their implication in liver pathophysiology, which might be informative to the translational medicine of targeting NRs and ncRNAs in liver disease.

【 授权许可】

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