Diastereoselective Ni-catalyzed 1,4-hydroboration of chiral dienols

TETRAHEDRON LETTERS

卷:56

Article

Ely, Robert J.¹  Yu, Zhiyong¹  Morken, James P.¹ 

[1] Boston Coll, Dept Chem, Merkert Chem Ctr, Chestnut Hill, MA 02467 USA

关键词: Hydroboration;    Platinum;    Polyketides;    Stereoselective;    Catalysis;   

DOI  :  10.1016/j.tetlet.2015.01.123

来源: Elsevier

【 摘 要 】

The Ni-catalyzed hydroboration of dienols occurs in a 1,4 fashion and delivers a syn-propionate motif in high diastereoselectivity and with a stereodefined trisubstituted crotylboronic ester. The boronic ester can be further manipulated to provide carbon-carbon or carbon-oxygen bonds. (C) 2015 Elsevier Ltd. All rights reserved.

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