Synthesis of new spin labels for Cu-free click conjugation

TETRAHEDRON LETTERS

卷:52

Article

Kalai, Tamas¹  Fleissner, Mark R.²  Jeko, Jozsef³  Hubbell, Wayne L.²  Hideg, Kalman¹ 

[1] Univ Pecs, Dept Organ & Med Chem, H-7602 Pecs, Hungary

[2] UCLA Sch Med, Jules Stein Eye Inst, Los Angeles, CA 90095 USA

[3] Coll Nyiregyhaza, Dept Chem, H-4440 Nyiregyhaza, Hungary

关键词: Amino acids;    Acetylenes;    Click chemistry;    Free radicals;    Spin labeling;   

DOI  :  10.1016/j.tetlet.2011.03.077

来源: Elsevier

【 摘 要 】

New pyrroline nitroxides attached to a terminal acetylenic sulfone, a dibenzocyclooctyne or a cyclooctyne carboxylic acid were synthesized and tested in Cu-free click reactions to conjugate these new spin labels with 4-azido-TEMPO, azidophenylalanine and an azidophenylalanine-containing protein. (C) 2011 Elsevier Ltd. All rights reserved.

【 授权许可】

Free