Azide/Alkyne Resins for Quick Preparation of 1,4-Disubstituted 1,2,3-Triazoles

Bulletin of the Korean chemical society

Dae Yoon Chi¹  Jae Hak Lee¹  Uthaiwan Sirion¹  Hee Jun Kim¹  Byoung Se Lee¹  Yu Jin Bae¹ 

关键词: Click chemistry;    Azide/alkyne resins;    1;    2;    3-Triazole;    Huisgen 1;    3-dipolar cycloaddition reaction;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

An efficient method for the preparation of 1,4-disubstituted 1,2,3-triazole compounds is described using polymeric quaternary ammonium salts having azide or alkyne functionality to remove unreacted excess starting molecules (azide/alkyne). Copper metal could easily be removed by simple filtration with a short Na2SO4/silica cartridge, affording highly regioselective products in high yield and excellent purity without the need for work-up, extraction and chromatographic purification.

【 授权许可】

Unknown