Bodipy-based photosensitizers with long alkyl tails at the meso position: efficient singlet oxygen generation in Cremophor-EL micelles

TETRAHEDRON LETTERS

卷:57

Article

Kilic, Bilal¹  Yesilgul, Nisa²  Polat, Veli³  Gercek, Zuhal³  Akkaya, Engin U.^1,2 

[1] Bilkent Univ, UNAM Natl Nanotechnol Res Ctr, TR-06800 Ankara, Turkey

[2] Bilkent Univ, Dept Chem, TR-06800 Ankara, Turkey

[3] Bulent Ecevit Univ, Dept Chem, TR-67100 Zonguldak, Turkey

关键词: Bodipy;    Photosensitizers;    Singlet oxygen;    Organic chromophores;    Organic photochemistry;   

DOI  :  10.1016/j.tetlet.2016.02.033

来源: Elsevier

【 摘 要 】

Bodipy dyes with n-decyloxyphenyl-(4, 5) and pentadecyl-(8) mesa substituents can easily embed themselves into micellar structures formed from Cremophor-EL. In micelles of approximately 20 nm median size, heavy-atom substituted dyes show remarkable photosensitization properties as evidenced by the rate of reaction with an anthracene-based selective singlet oxygen trap in buffered aqueous solutions. Considering the ease of Bodipy derivatization and the advantages of Cremophor-EL carried therapeutic agents, these photosensitizing agents may offer novel targeting opportunities and enhanced chemical and photophysical stability. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free