Facile synthesis of mutagen X (MX): 3-chloro-4-(dichloromethyl)-5-hydroxy-5H-furan-2-one

TETRAHEDRON LETTERS

卷:53

Article

Velvadapu, Venkata¹  McDonnell, Mark E.¹  Jaffe, Eileen K.²  Reitz, Allen B.¹ 

[1] Fox Chase Chem Divers Ctr Inc, Doylestown, PA 18902 USA

[2] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA

关键词: Mutagen X;    Furanone;    Chlorine;    Mucochloric acid;    Mutagenicity;   

DOI  :  10.1016/j.tetlet.2012.04.044

来源: Elsevier

【 摘 要 】

3-Chloro-4-(dichloromethyl)-5-hydroxy-5H-furan-2-one (mutagen X, MX) was synthesized in six steps from commercially-available and inexpensive starting materials (27% overall yield). This synthesis enables the preparation of MX analogs and does not require the use of chlorine gas, as do previously reported methods. (C) 2012 Elsevier Ltd. All rights reserved.

【 授权许可】

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