Solvent- and metal-free hydroboration of alkynes under microwave irradiation

TETRAHEDRON LETTERS

卷:61

Article

Gioia, Bruna¹  Arnaud, Alexandre¹  Radix, Sylvie¹  Walchshofer, Nadia¹  Doleans-Jordheim, Anne^2,3  Rocheblave, Luc¹ 

[1] Univ Lyon, Univ Claude Bernard Lyon 1, ISPB Fac Pharm, EA 4446,B2MC, F-69373 Lyon 08, France

[2] Univ Lyon, Univ Claude Bernard Lyon 1, VetAgro Sup, UMR CNRS 5557,Ecol Microbienne, F-69622 Villeurbanne, France

[3] Hosp Civils Lyon, Ctr Biol & Pathol Est, Lab Bacteriol, F-69000 Bron, France

关键词: Hydroboration;    Alkynes;    Microwave;    Solvent-free conditions;   

DOI  :  10.1016/j.tetlet.2020.151596

来源: Elsevier

【 摘 要 】

Boronic esters are versatile building blocks extensively used in organic chemistry and essential to a variety of coupling reactions. In this work, the hydroboration reactions of alkynes were performed without metal catalysts using concomitant microwave irradiation that allowed a significantly reduced reaction time. Another interesting outcome of this study was that the reaction could be carried out under solvent-free conditions, highlighting the environmentally-friendly nature of our method. A wide scope of aryl- and alkylboronic acid pinacol esters were easily synthesized from the corresponding alkynes. (C) 2020 Elsevier Ltd. All rights reserved.

【 授权许可】

Free