An efficient boric acid-mediated preparation of α-hydroxyamides

TETRAHEDRON LETTERS

卷:51

Article

Kumar, J. Sravan¹  Jonnalagadda, Subash C.²  Mereddy, Venkatram R.¹ 

[1] Univ Minnesota, Dept Chem & Biochem, Duluth, MN 55812 USA

[2] Rowan Univ, Dept Chem & Biochem, Glassboro, NJ 08051 USA

关键词: Multicomponent reactions;    Isonitriles;    Boric acid;    Benzoxaboroles;   

DOI  :  10.1016/j.tetlet.2009.12.008

来源: Elsevier

【 摘 要 】

An efficient methodology for the preparation of alpha-hydroxyamides via boric acid-mediated addition of isonitriles onto aldehydes has been developed. The reaction of isonitriles with alpha-boronobenzaldehyde takes place under intramolecular catalysis conditions to provide functionalized benzoxaboroles. (c) 2009 Elsevier Ltd. All rights reserved.

【 授权许可】

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