Synthesis of α-carboranyl-α-acyloxy-amides as potential BNCT agents

TETRAHEDRON LETTERS

卷:50

Article

Jonnalagadda, Subash C.¹  Cruz, Jonathan S.¹  Connell, Ryan J.²  Scott, Patricia M.³  Mereddy, Venkatram R.² 

[1] Rowan Univ, Dept Chem & Biochem, Glassboro, NJ 08051 USA

[2] Univ Minnesota, Dept Chem & Biochem, Duluth, MN 55812 USA

[3] Univ Minnesota, Dept Biochem & Mol Biol, Duluth, MN 55812 USA

关键词: Multicomponent reactions;    Isonitriles;    Carboranes;    Low-density lipoprotein;    Boron neutron capture therapy;   

DOI  :  10.1016/j.tetlet.2009.05.026

来源: Elsevier

【 摘 要 】

Novel alpha-carboranyl-alpha-acyloxy-amides were prepared as potential BNCT agents utilizing three-component Passerini reaction. Preliminary cytotoxicity of the representative compounds on two brain tumor cell lines (U-87 and A-172) showed no effect on cell viability; an essential requirement for utility as potential BNCT agents. (C) 2009 Elsevier Ltd. All rights reserved.

【 授权许可】

Free